Disease, Medication and Healthy Lifestyle

Posts Tagged ‘diabetes’

Patients with heart disease who take anti-clotting drug Plavix is safe to take medicine to relieve stomach acid type Proton Pump Inhibitors (PPI), the analysis of two previous studies.

The discovery is currently being developed seem to actually appear contradictory with previous research, which found that heart patients who take Plavix, just get a negative effect when combined with PPI type drugs, especially Prilosec.

In the latest study, reported in March 2009, heart attack patients who take Plavix with PPI are more likely to suffer a second heart attack compared with other cardiac patients not taking Plavix without a combination of PPI.

Plavix and anti-clotting drugs such as Effient, which was approved by the FDA, given to patients with blockages in the heart and is given along with aspirin to prevent clots or blockages in blood vessels that lead to a second heart attack or stroke.

PPI such as Prilosec, Nexium, Prevacid, and Protonix, sometimes given to reduce the risk of gastrointestinal bleeding due to anti-clotting drug administration.

PPI has no problem when mixed with Plavix
Recent analysis showed no increased risk of heart attack, stroke, or death in patients taking PPI and Plavix or Effient.

“We found no association between PPI with an increased risk of cardiovascular disorders for patients taking these two drug classes,” said chairman of the study, Michelle L. O’Donoghue, MD. “This raises questions about why the study conducted recently showed differences with the previous analysis.”

One theory is that there is a possibility given PPI in patients with severe heart disease or have been berkomplikasi. Two large studies, involving about 13 600 patients who have a history of heart attack or unstable angina treated with one or two drugs. Patients in this study were younger and very little has a history of diabetes or kidney failure compared with patients who participated in previous research that has a more severe condition with the use of PPI.

“This may explain why patients given PPI in previous research to have unfavorable outcomes,” said O’Donoghue. One third of patients in this study is also taking PPI PPI but here probably was not linked to increased risk of second heart attacks, stroke, or cardiovascular disorders even in combination with anti-clotting drug.

PPI Not Suitable for All Cases
Research published in the journal The Lancet is said that the PPI and anti-clotting drugs can be safely combined in patients who did have an indication of the use of either drug. But the PPI should not be given to all patients who take Plavix or Effient. In the editorial, Dirk Sibbings researchers wrote that the use of PPI can have if given the risk of heart disease in subpopulations of patients who have a genetic predisposition to reduce the work or the response of anti-clotting drug.

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