Disease, Medication and Healthy Lifestyle

Archive for the ‘Spondylitis’ Category

Ever wondered that nearly one-third in your life is actually passed sleeping? However, until you have tried a total pillow, you haven’t in any possibilities considered how beneficial a pillow might be.

Dubbed as the a lot functional cushion ever, you can utilize this cushion in your bed, or even while you are watching television or even even while doing work at the table with your laptop or computer. You’ll be able to use this while on a aircraft, in a automobile or even while actively playing a video game.

This pillow is filled with mini beans. The main cover is in fact made up of brushed microfiber stretchable material. It is dough-nut designed. It may be squeezed conveniently to supporting plus unique styles. You may use the cushion with any of these designs to support the head and neck in any particular position with the entire body. You may also put it to use to aid your lower part of spine, back or knee and ankles.

Lots of people suffer from back problems sitting long hours on their particular desks in their business office. Back problems can also happen whilst driving automobiles.

Most of the time, the typical seats that individuals make use of for a relatively long hours are not anatomically developed. Anxiety as well as pressure build up in our back area due to incorrect position.

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If you have underwent any surgery treatment, or have experienced an accident, you’ll need a correct back support to prevent complications as well as recover quicker. In every one of these conditions, a good back pillow just like the total pillow is going to be of big advantage to a person.

The bone tissue arrangement together with muscles of our lumbar part tend to be such that applying excessive stress to the back area is certain to successfully bring about issues like Spondylosis which might typically become crippling. Utilizing a lumbar assist cushion is usually a cheap in addition to secure technique to assist the back.

Apart from back ache, neck ache and even tender shoulder are always very uncomfortable. Typically, these kinds of problems crop up from your completely wrong position. This kind of cushion is definitely immensely suitable for these types of health conditions. The pillow may be shaped any way you prefer and will stay on pretty much locked in that particular arrangement. A few of the techniques it functions are just as listed below.

– Regarding cervical neck assistance, the total pillow could be twisted and converted into a customized headrest.

- Ones lumbar area may be aided to relieve stress in your vertebral disk. In case you have to be seated for long hours, working on say your pc, such back comfort is actually mandatory.

– It can be used to help ably assist ones shoulder joint.

– In case you are laying on the floor, you can use it like a floor pillow.

– Whilst venturing by means of aircraft, or even traveling long-distance by vehicle, it is possible to turn the item into U shape and therefore turn it into a really relaxing traveling pillow.

This specific pillow is fairly reasonably costed. A few retailers even offer you a single free for every 1 buy at price .99 cents plus shipping and also handling costs.

Total pillow is really a multipurpose pillow that covers the requirement for cushions on all events. It really is reasonably priced as well as is definitely a must have to really feel peaceful as well as reduce discomfort.

If you are a person that tries to consume as healthily as feasible, then you unquestionably get health supplements. It is virtually not possible to get all the vitamins and nutrients that your entire body wants from just eating particular foods. For these that do not consume healthy, it is important to comprehend that dietary supplements are not a substitute for a excellent diet plan. There are consistently new types of health supplements and nutritional vitamins produced obtainable, and amid them are green mussels. These unique creatures possess fairly a bit of really wholesome nutrients, and are really advantageous when applied as a supplement.

 

These green mussels are solely from the waters all-around New Zealand. The rationale that they get so loaded with nutrients is since of the minerals and phytoplankton in the ocean. When these mussels get to their highest stage, they are taken and every thing but the shell gets freeze dried. By freeze drying them, the nutrients continue to be active. Of course, the incredible aspect about them is the myriad of positive aspects that they have for both humans and animals. They are regarded to reduce pan and lower again on inflammation, and they can assist to alleviate the signs and even get rid of quite a few bodily troubles.

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Some of the factors that green mussels can aid consist of degenerative joint conditions like Osteoarthritis, as very well as Bursitis, Rheumatoid Arthritis, Lyme condition, Ankylosing Spondylitis, inflammatory complications with the skin, and injuries that are related to sports. They can also enable with fix of the connective tissues. In other words, they are quite very good for your joints and everyone that is dealing with ache in these regions would be properly advised to begin taking them. They also have a big sum of protein which is exceptional for regulating system bodyweight and building muscle.

 

So regardless of whether you are somebody that just needs to avoid bone conditions like osteoporosis and osteoarthritis or problems with joints or you are seeking for relief from people factors ideal now, you need to take into account supplementing your diet plan with green mussels. And whilst they are total of nutrients, they are not a beneficial substitute for a wholesome, effectively balanced diet plan and reasonable physical exercise each and every day.

 

Maxavita provides top quality green mussels products.

Back pain that affects about 90% of people is the most happening physical disorder after cold and headaches. It comes with varied symptoms each representing a different cause and accordingly the treatment is specified. Very often accidents, over strenuous sports activities can result in back pain. But the most common reason is the muscular strain and sprain that can arise due to different causes. It is such a bothering condition that apart from restricting the movement one can’t sit comfortably for long and in serious conditions long bed rest is also advised. Blame it on the sedentary lifestyle or overstress, back pain is one of the main reasons for missing out a good number of working days in US.

Back pain symptoms

The severity of the back pain depends on the causes and the symptoms can be listed as –

1. Intense or acute back pain generally has brief existence lasting for several days or a week.
2. Pain continuing for more than 3 months can turn chronic.

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3. Back pain arising from torn ligaments remains confined to a particular area.
4. Low back pain may or may not extend beneath the thighs up to the feet.
5. The pain may be followed by tingling sensations in the leg.
6. Often the acute back pain arising due to compressed nerve may cause numbness in the legs.
7. Pain may be felt while coughing or sneezing.
8. Prolonged sitting or standing may worsen the condition.

Causes

Back pain also comes with a number of causes some of which are –

1. Muscular strain and sprain with the tearing of ligaments and muscular fiber.
2. Arthritis or bone degeneration due to aging.
3. Any back injury
4. Obesity
5. Degeneration of the spinal discs.
6. Spondylosis that occurs with age.

Treating back pain

1. Yoga and exercises help in treating the back pain, as exercises help in improving the elasticity of the ligaments and joints and provides better blood circulation.

2. Applying hot water bags regularly also helps in relieving the pain.

3. Various anti-inflammatory and pain relieving drugs are advised in treating back pain. The acute cases may require corticosteroid injections or even surgery.

4. Ginger roots have anti-inflammatory properties and prevent the production of leukotrienes and prostaglandins, which are responsible for inflammation.

5. Application of hot peppers like Cayenne pepper and Red capsicum supplements reduce the back pain to a great extent. These contain a compound called capsaicin that helps in treating this condition.

6. Drinking few cups of Chamomile, horsetail tea regularly also reduces this problem.

7. Massage with Rumatone Gold oil helps in treating the back pain.

The Aires massage chair comes in the forge of a fixture cask chair. It is handsomely fashioned and leave hands most interiors. It is the perfect enunciate chair for your interior or staff.

This all air massage chair comes with 19 airbags. There are 14 airbags for the feet and calves incomparable. It comes with two airbags for the hindermost, two airbags for the waist and one for the tooshie.

It also has an reflex massage package as compartment as recitation massage modes. You can centre the massage in a fact country in the drill way or get a stentorian body massage in the involuntary way. The manual massage modes estimate you to butt the feet and calves, the waist or the support.

The Aires massage chair also comes with a remote prove. The far hold fits comfortably in the palm of your hand. It enables you to conform it supported on your needs.

This chair also comes with a motorized leg rest. The leg quietus can be large with the urge of a secure on the removed curb. Likewise, you can also retract the leg pose by using the remote prove.

Low sustain anguish results from a musculoskeletal modify of the lowly hinder. It can amount in different degrees of anguish place. Some things can be the entity of low affirm somesthesia, but most typically it is caused by muscular strain, accident to the devalue approve including the discs, ligaments, and muscles that are close the spine country. There are a difference of treatments depending on exactly what is effort the discompose, but one communication that is gaining popularity is massage chairs.

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Most group at one tip or another in their lifetime leave receive whatever stage of low rearward painfulness. It may be caused by indisputable disorders of the move rear, loss or just unornamented over utilization. Whatever of these causes can be prevented where others may become as symptoms from another diseases.

Several inferior disorders affecting the backbone are Pagets disease, Ulcers Scheuermanns upset, Ankylosing spondylitis, Pancreatitis, Pelvic inflammatory disease and Spinal pathology. These conditions are good burnt by a medical dilute. The treatments for these conditions comprise from medication to surgery and may postulate tangible therapy as division of the feat knowledge.

Massage chairs bonk the susceptibility to distribute friction. Friction is utilized to move out a surrendered set of muscles. The propulsion massage applies friction to the vertebra in the rachis. Apiece vertebra is separately focused as the rollers procession up the length of the spine. Massage chairs can touch friction to the subaltern embody and to the assemblage and shoulders.

If you are effort a massage, you strength as healed modify. Massage chairs combine MP3 Players where you can witticism fleecy soothing punishment. Penalisation helps the care to affect and to let go. This letting go releases the enmity in the muscles that the intellect is retentive. This provides an useful environs of operation in what may usually be a work location in offices today.

Most group wad with rearward hurt at whatsoever taper in their lives. It can be caused by an injury, biology, and straight bad capability. Posterior upset, especially inveterate backmost feeling, is real ruffian to mess with and it can gravely combat your living. More grouping round to massage healthful and it activity. Perception a massage therapist formerly per period helps umteen fill raft with position discomfit so they can smoldering their lives easier. Massages are also therapeutic for relieving hostility, symptom, and punctuate from our muscles, bodies, and familiar aliveness.

The secret of long life is Good Health.

Now days in stressed daily routine everybody require some relaxation.
Ayurvedic Massages, which should be a daily routine to lead a healthy and normal life.

One of the best massage that’s is prescribed goes by the name of “SIRODHARA”. This massage is done with special medicated oils. These medicated oils are specially prepared with various herbs and decoctions to suit all body types, either Vata, Pitta or Kapha, in special earthen pots over fire wood. This is then gently poured from a pot along a thread on to the forehead alongwith a mild massage. The procedure starts with tying a varti around the head, “VARTI” is linen cloth rolled like a string, which is used for tying. This helps the therapist to outline the exact position where the oil should drop; taking care it does not go into the eyes. After a liberal application of the medicated oil on the head and body, the guest is made to line supine on the special wooden bed “DRONI”; with his neck and head placed in a comfortable position. Care is taken to measure the particular height that the pot has to be placed over the forehead, to give the expected soothing to the head. All this procedure is meticulously done, which thus gives the best result after performing the therapy. This dripping of special medicated oil gently on the forehead activates the pituitary glands and stimulates the whole body. This massage is like an analgesic and designed to relax, revive and restore your body and mind. Along with the treatment of the head simultaneously the body is also handled with. Again special oil for the body is prepared with almost twenty varieties of special plants processed with milk and decoction. The body is rubbed lightly all over with this medicated oil. At the age of twenty or early thirties the anabolic state of the body may stop and the catabolic state takes over. The catabolic changes will effect both the body and mind; manifestations like wrinkles, sagging of skin, joint problems, lethargy, loss of memory, lack of sleep, lack of concentration, general weakness etc. are seen. To overcome all this, the best remedy is “Kairali’s” Sirodhara. Moreover, in today’s fast paced life and trying to catch up with targets and job pressures, one is full of stress. This day-to-day pressure and stress leads to various disorders in the body like neck pain, stiffness and Spondylitis.

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The natural and toxic free way of relieving oneself from this malaise is the traditional therapy Sirodhara.

The overall benefit that one could gain from this therapy is it relaxes and invigorates the body and improves strength and strengthens the immune system there by preventing the body from disease, equalizes circulation and increases metabolism, enhances penetration of nutritional substances from the oils, relieves stiffness, soreness and pain, increases muscle tone and nerve functioning. All this can be achieved just at your doorsteps. The 5000-year-old medical science is practiced and perfected by “Kairali” as prescribed in the ancient Indian medical lore.

“KAIRALI” practices fitness through massages; and Sirodhara is one massage with medicated Herbal Oils; that builds up the stamina and energy and protects the body from ailments and illness. Briefest visit to “Kairali” however instills a profound change.

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Lower back pain or lumbago affects more than 80% of the people at some stage of life and can be very bothering. No specific reason can be assigned for this disease and the pain can be chronic, moderate and acute. This musculoskeletal disorder impedes free movement of an individual and the serious cases often demand total bed rest. The symptoms sometimes persist for a week and subside and may relapse after a gap of few weeks or months.

Symptoms

The following symptoms are the indications of Lower back pain -

1. Pain in back while bending, moving and walking.
2. The pain is felt in the buttocks and pains that can last for 48 to 72 hours.
3. Often the pain may extend below the knee to the foot and ankle.
4. Pain felt while sneezing and coughing.
5. Stiffness in the back and the hip muscles.

Causes

Though back pains don’t have any specific cause but some underlying reasons can be:

1. Any injury to the back muscles, spine and back bone that can result in this problem.
2. Abnormal functioning of the abdominal organs.
3. Pressure on the nerve roots or Sciatica is another factor.

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4. Degeneration of the spinal discs.
5. Spondylosis, Fibromylagia and Osteomyelitis are other causes of lower backache.
6. Even smoking can cause lower backache.

Treatment

In case of moderate and sub acute back pains some self care treatments and medications are enough to cure the disorder but in chronic cases regular exercises with due precautions must be carried to keep the pain in check.

1. Sleeping with pillows in between the knees or sleeping lying on the back with knees resting on the pillow gives some comfort and so are often recommended by doctors.

2. Exercises are beneficial for chronic back pain as it improves the blood circulation in the muscles.

3. Some backache may require long bed rest depending upon the severity of the pain.

4. Painkillers like ibuprofen and acetaminophen are prescribed to relieve the back pain.

5. Application of heat and ice packs are also found to be beneficial in some cases.

6. Application of a pack of black mustard seeds produces intense heat that lowers the back pain.

Low back pain symptoms are sometimes just bothersome, such as dull aches or tenderness, but can be severe in some cases. That’s why you need to be able to target the pain, learn about the symptoms that you’re experiencing, and know when you need to see a doctor and when you can just wait it out to see if it goes away. In some cases, symptoms can even seem like they’re related to low back pain but be the root of a different problem, such as when you have kidney problems or shingles, which is common in older adults.

Make sure that you are aware of where the acute pain is, what symptoms accompany it, and how severe it is. You never want to assume that it’s just a sore muscle when the pain is too much to bear, because this could lead to prolonged injury, permanent damage, or even severe illness because you didn’t recognize that it wasn’t actually back pain at all. Keep these things in mind when checking out your symptoms and you’ll be better prepared.

Joint pain can indicate a comparatively benign condition, such as mild sprain. Joint pain can be the result of a moderate condition, disorder or disease, such as bursitis, ankylosing spondylitis, a moderate ligament sprain, or a dislocation. Joint pain can also accompany serious conditions that can even be life-threatening.

Joint Pain Causes

Joint pain can be caused by injury or sickness touching any of the ligaments, bursae, or tendons nearby the joint. Injury or illness can also influence the ligaments, cartilage, and bones within the joint, most important to a painful joint

Joint Pain Symptoms

Pain is the chief symptom of most musculoskeletal disorders. The pain may be mild or severe, local or common (diffuse).
Although pain may be acute and brief, as is the case with most injuries, pain may be constant with chronic illnesses, such as rheumatoid arthritis

Most Important Tips for Joint Pain: -

•    Apply Eucalyptus oil where there is pain. Steam the affected area or dip a towel in boiling water, twist the water out from the towel and apply it to the affected area.

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•    Have one tea spoon of cod liver oil every day-Stick to the one tsp measure. Avoid use of too much pain killers especially those containing narcotic and sleeping tablets.

•    You can have a look at your diet as there are some products that will exacerbate the pain. Sometimes dairy products, citrus, alcohol, some meat, beef, pork, lamb, and vegetable oils have inflammatory effects and if your condition is inflammatory then this is a joint pain remedy that you should consider. You can find a good arthritis diet out there for you.

•    Have lots of fruits containing Vitamin C like Guava, Oranges, and Gooseberries. Try avoiding milk and potatoes.

•    Usually Joint pain is felt more in the morning. Apply some ointment on the affected area before going to bed everyday.

•    Simple exercises in Yoga, Cycling, Swimming, Walking etc. can control the pain. Keep the exercises simple and do not overexert. Doing exercises standing in chest level water also improves the pain.

•    Proper posture should be maintained while sitting, walking and lying down.

•    If overweight, control weight by reducing food and doing exercises.

•    Prepare a mixture by mixing equal quantity of carrot juice and lemon juice. Consume one tablespoon of this mixture daily is one of the best remedy for joint pain. Carrot juice strengthens our ligaments to a great extent.

•    Drinking papaya seed tea has a positive effect in relieving join pain. Drink this tea at least 4-5 times every day for at least two weeks before you can see some results.

•    Drinking of plenty of water is effective in bringing down joint pain. Water is excellent for the purpose of flushing out the toxins from the body and providing joint pain relief.

•    When warm milk is inspired by adding one table spoonful of turmeric, it is an excellent remedy for joint pain relief.

•    Grind four peeled pieces of garlic, along with two grams of Sprague. Dip this mixture in 30 grams mustard oil and heat, on low flame, for 1-2 minutes. Massage the aching joints with this oil, after cooling it down, to get release from pain and swelling.

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Over the past 50 years or so, science has been able to unlock the mystery of enzymes and has applied their knowledge to make better use of these amazing substances in an ever growing number of applications.  One of the key benefits of enzymes is in the sphere of human health care.

The human body and its trillion cells use and depend upon thousands of metabolic enzymes for their energy factor and to carry out numberless biochemical processes.  Metabolic enzymes act as the workhorses of the body because they also regulate and control each and every process that keeps the body functioning harmoniously.

As a consequence, their therapeutic applications are varied and far-reaching, from the treatment of chronic pancreatitis to the lysis (the disintegration or dissolution of cells such as blood cells or bacteria) of blood clots especially for treating cardiovascular diseases.

Germany is the country that has performed most of the pioneering work in the field of Enzyme Therapy.   Hans Nieper, Dr. Max Wolf and Dr. Benitez succeeded in showing that mixtures of enzymes had a positive effect in reducing swelling and inflammation; enhancing immune function; improving circulation; reducing pain; strengthening connective tissue; speeding recovery from traumatic injury; minimizing scar formation; preventing complications after injury and also found them to be useful in the management of rheumatic diseases like rheumatoid arthritis, soft tissue rheumatism and ankylosing spondylitis.

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In recent years, certain proteolytic enzymes such as serratopeptase and nattokinase have been employed for their fibrinolysis properties because they possess the ability to emulsify and digest arterial plaque.  Others like bromelain and papain have shown mucolytic activity and have been found to be helpful in treating respiratory tract diseases such as sinusitis and bronchitis.  Yet others have an anti-inflammatory effect, helping to decrease swelling, capillary permeability and reducing blood viscosity by dissolving blood-clot forming fibrin deposits and micro-thrombi thereby improving oxygen and nutrient transport and circulation.

Proteolytic enzymes act as a natural anti-inflammatory and have also demonstrated the ability to break down plasma proteins and cellular debris into smaller fragments at the site of an injury helping their dispersal through the lymphatic system.  This is turn relieves swelling, pain and discomfort.  Because of their healing properties they have been found to be excellent therapeutic agents for minor musculoskeletal injuries and for accelerating recovery in sports injuries, surgery and burns.

Proteolytic enzymes are useful in the fight against bacterial and fungal infections.  When it comes to fighting viruses – enzymes attack and dissolve the isoprin bonds – the exterior protein shell coating of the virus, rendering it useless.  And last but not least, enzymes modulate immune function by enhancing the production of cytokines, increasing the phagocytic activity of macrophages and facilitating the break-up of circulating immune complexes which are the major causes of auto-immune diseases such as arthritis, rheumatoid arthritis and multiple sclerosis.

Enzymes target a diverse range of ailments, are 100% natural and offer noticeable and rapid health benefits.

www.advanced-supplements.com

The present article is relaed to the observation made by the author in his two and half decades of clinical practice on the cure of the divergent inflammatory diseases such as Asthma, Arthritis, Tuberculosis, etc. by administering a single molecule/ medicine. Extensive literature and patent search could not present any scientific explanation for the phenomenon observed and reported. Preliminary research at the author’s clinic and lab has enabled the postulation and confirmation of a novel theory and immune pathway involving Histamine haemostasis referred to as the Rao’s Vicious Cycle.  In this study the medicine used belongs to the category of allergies, a new mechanism is proposed for the action of mediators during the inflammation. It has been postulated that the histamine liberated from the mast cells is the key link among the divergent diseases. During inflammation, histamine is released at the inflammatory sites as predicted by Rao’s vicious cycle. The later refers to the proliferation of TH2 type of reaction and its dominance over TH1 reaction.  In this method of cure known as Appa Hista, antihistamine antibodies, combat the histamine at the inflammatory sites and also block TH2 type of reaction, thus indirectly helping the TH1 type of reaction. The dual effect of Appa hista antibodies has been visualized in 1) Killing the intracellular organisms through TH1 type of reaction and; 2) Neutralizing the histamine at inflammation site at the same time blocking the excess TH2 type of reaction. Since Appa Hista directly attacks histamine where ever it is present, it may cure all inflammatory diseases.

            The present investigation deals with the cure of some of the most stubborn problems such as paralytic stroke, arthritis, tuberculosis etc., by using histamine conjugated normal human immunoglobulin.  Histamine is a chemical mediator and also the prime mediator of inflammation.  It is a vasoactive amine, found long back and established as a chemical mediator of inflammation.  This compound is essential for vascular permeability and allows the vessels to leak the protein rich exudate and cells to the site of inflammation. The latter is divided into two groups: 1) Acute inflammation and 2) Chronic inflammation. While chronic inflammation may originate as chronic itself, an acute inflammation, may, over a period of time become chronic.  The inflammatory response is closely coupled with the process of healing or repair.  A foreign body (agent) always wants to destroy the host tissue for its settlement, while, the host always tries to get rid of the agent as it is foreign.  Thus, inflammation can be considered as a protective response of the host and serves to destroy, dilute or wall off the injurious agents, and, also as far as possible heal and reconstitute the tissues.

            Normally, inflammation is an immunological (protective) phenomenon and, pain is a protective signal to get rid of the stimuli (causes).  At times they become pathological and produce disease.1 Repair begins during the early phases of inflammation but reaches completion usually after the injurious influence has been neutralized. During repair the injured tissue is replaced by parenchymal (functional) cells or by filling of the defect with fibroblastic tissue (scarring) or most commonly by a combination of these two processes.  The defense mechanism is such that the system tries itself best to give protection by innate immunity. Alternately, if the agent is a stronger one, then only the acquired immunity is triggered either by humoral immunity (present in body fluids) or by cell mediated immunity or by both.  The humoral/cell mediated immunity is offered by several preformed or existing proteins like compliment and antibodies, or, by cells like macrophages, lymphocytes and neutrophils.  When an agent initiates an injury, the defense mechanism is triggered by release of mediators.  Rather than too few, there are a large number of mediators in the defense system.

            The cells that are developed in the bone narrow mature and liberate into the blood stream.  A few cells settle in the tissues and lympho reticular system to perform their immunological function.  The cells in the blood are red blood cells (RBC) white blood cells (WBC) and platelets.  Red cells supply oxygen to all the systems.  White blood cells defend body from foreign stimuli and platelets help in clotting.

            The WBC is further divided into Granulocytes, lymphocytes and monocytes.  It is well known that granulocytes are further divided into polymorpho nuclear leucocytes, Eosinophils and Basophiles. Lymphocytes are divided into T cells, B cells and NK cells.  Monocytes are referred to as monocytes in the blood and as macrophages and mast cells in the tissues.

Mediators are found in cells as well as in plasma. Mediators are classified into preformed mediators and newly synthesized mediators. Preformed mediators always exist even in the absence of the inflammatory stimuli.  These are histamine, serotonin, lysosomal enzymes which are generated by the cellular sources mast cells, platelets, neutrophils, macrophages etc. The newly synthesized mediators, on the other hand, are formed in the presence of an inflammatory stimulus.  These are prostaglandins, leucoterines, and platelet activating factors, cytokines, and nitric oxide etc., generated from cellular sources such as leucocytes, platelets endothelium and macrophages.

            Under the influence of an inflammatory stimulus certain proteins in the plasma like complement under go chain reactions releasing intermediary substances like C3a, C5a and C5b – 9.  C3a is an anaphylotoxin attracting histamine to the site, while C5a attracts neutrophils to the site.  C5b – 9b, on the other hand, are believed to create MACs (membrane activating complexes) and cause target cells lysis (destruction). A plasma protein known as Hegeman factor, on the other hand, activates, clotting/ kinin cascades resulting in blood clotting and pain.

            The response initiated by an antigenic stimulus in the cells and mediators in a host is known as immune response.  As is well documented IR can be divided in to two types such as the humoral (antibody mediated immunity (AMI)) and the cellular (cell mediated immunity (CMI)). AMI refers to interaction of antigens with antibodies present in the plasma and in the interstitial fluids (extracellular), resulting in neutralization.  CMI refers to the direct killing (lysis) of intracellular bacteria through various cytokines secreted by T lymphocytes.

            The current state of understanding regarding immunological reactions can be summarized as follows.  Briefly the I Anaphylactic, II Cytolytic and III Immune complex reactions eventually generate TH2 (T Helper cell sub set 2). The latter generate the IL4 IL5 and IL10 (interleukin cytokines) which take part in allergic reactions, basic healing and also provide opposition to the TH1 subset. TH1 subset forms in delayed type of hypersensitivity reaction (type IV) and includes the cytokines IL2, TNF and IFN contributing to intracellular killing.

 

Two decades of clinical practice in curing various inflammatory diseases and the possible common link between these is summarized in Table 1. The latter clearly points out the administering of the medicine for a primary disease such as Asthma which was found to have a beneficial affect on Arthritis, and so on.  Thus, a single medicine normally used in treatment of allergies had resulted in cure of several inflammatory diseases which are hitherto being treated separately.  Animal experimentation at All India Institute of Medical Sciences (AIIMS) confirmed the anti inflammatory properties of the medicine.2 This necessitated a re-look in to the fundamentals of cells, mediators and immunological response.  Literature and patent search revealed that in 1994 a US patent was granted to Yoshi et al from Japan.

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Subsequently relief by the treatment has been observed in the following inflammatory diseases;

Rheumatoid arthritis, SLE, Seronegative arthropathies, including reactive arthritis, ankylosing spondylitis, psoriatic arthritis, and various vasculitides.

Paralysis (Cerebro vascular accident due to vasculitis), Encephalitis, Tuberculomas, multiple sclerosis, Epilepsy, peripheral neuritis, migraine, Guillian-Barr’e syndrome.

Bronchial asthma, TB, Drug resistant tuberculosis, and pulmonary mycotic conditions.

Glomerulo nephritis, chronic renal failure, nephrotic syndrome.

Chronic UTI, Stress incontinence, chronic leucorrhoea, and infertility.

Hypertension, Rheumatic heart diseases, (also with CCF, Choria) Congestive cardiac failure, Atherosclerosis. Global hypokinesia.

Chronic venous (Sephanous) ulcers, psoriasis, Lepraneuritis, and Vitiligo (Early Stage).

Iridocyclitis, Uveitis, Retinal detachment, Glucoma, Vasomotorrhnitis, Epistaxis, Allergy, Miners disease.

Peptic ulcer, IBS, Ulcerative colitis.

Stress related syndromes. Dementias.

Cerebral Malaria, Filariasis, Fungal infections and DIC.

Cancer pains, chronic pains, few cancers arrested.

Thyroid, Diabetes.

 

 

COMMON LINK AMONG INFLAMMATORY DISEASES

Reorganization of cells

In the present methodology, the cells are reorganised into cells presenting antigens, cells required in processing antigens and intermediary cells, and, cells found at the site of inflammation. Of particular importance is the role played by intermediaries such as mast cells and basophiles. As will be seen later these are essential for release of histamine, and therefore, key agents for initiating and maintaining the inflammation.  It is thus imperative that any control on mast cells should control the inflammatory diseases.

Mast cells

Mast cells4,5are bone marrow derived tissue resident cells, relatively large in diameter (10-15 mm) and heterogeneous in shape.  Under optical microscope the mast cells reveal 50 to 200 densely packed granules in each cell, each granule in turn is bound to membrane. A typical granule of 0.1 to 0.4 mm contains relatively large amounts of histamine, heparin, TNF and other preformed inflammatory mediators.  The surface of the each of the cells is coated with high affinity receptors ecoR1, which attracts IgE molecules on the surface of mast cells. Following the attachment of the IgE molecules on the mast cell surfaces, the granules start degranulating.  Although mast cells are found in connective tissues through out the body, these are present in large numbers beneath the surface tissues such as skin, lung alveoli, gastrointestinal mucosa and nasal mucus membranes. Thus, mast cells are strategically positioned to interact with inhaled or ingested antigens.

Mechanism of Mediators:6

            Histamine at the inflammatory site has a long life (30-60 mts), and, is stable as compared to most mediators derived from phospholipids and nitric oxide.  As is well known histamine triggers all the mediators and vice versa. Therefore, in any physical injury such as trauma, cold or heat, the activation of already stored histamine from the mast cells is expected to play a dominant role.

 

Histamine receptors on lymphocytes:7,8,9 

            In the proposed protocol it has been postulated that histamine can trigger lymphocytes in releasing other mediators.  This is possible only if there is histamine receptors present on the lymphocytes.  This assumption has received a recent support from several researchers. Similarly, the action of T cells in the histamine homeostasis10 (self-regulating information feedback) is proposed to take place as illustrated in Fig. 1. An important point to note is that IL6, IL8 and TNF etc., present at the inflammatory site due to tissue injury are also capable of liberating histamine.

 

IgE B Cells:

            The IL4 cytokine is expected to play a dominant role in sensitizing CD4 cells and through it the effector cells i.e. B cells and CD8 cells.  Further, in a double pronged manner IL4 can directly sensitize an IgE B cell which in turn releases IgE and acts on mast cells to liberate histamine.  The latter in turn goes to the inflammatory site and causes healing through TH2 type of reaction.  In case the inflammation is larger, it may turn in to chronic due to liberation of cytokines IL4 IL6 TNF etc.11  These in turn, in a positive feed back cycle, trigger histamine release and aid in maintaining chronic inflammation.  This vicious cycle of generation of histamine at the site of injury and its subsequent triggering of IgE B cells ( Histamine pathway II) and CD4 cells ( Histamine pathway I) is termed as Rao’s Vicious cycle.  That is strong inflammation can turn into chronic inflammation by the continuous generation of excess histamine in repeated positive feed back cycles.  Micro organisms may be exploiting this phenomenon in producing chronic inflammation and autoimmune diseases.

 

Rao’s Vicious Cycle and it’s interaction with three immunological pathways

            As is well known, any immunological reaction operates through three different path ways as shown in Fig.2.  The path way 1 is known as IgE / mast cell / mediator path way can be sub divided to reflect physiological and pathological conditions as path 1a and path 1b respectively.  It can be noticed that in all the physiological conditions histamine is liberated and together with TH2 affect the cure.  The pathological conditions of inflammation on the other hand may turn in to chronic inflammation due to the excessive generation of histamine in a cyclic manner as explained earlier by Rao’s vicious cycle.

            Fig. 2 depicts the details of physiological and pathological path ways.  The difference between the 3 path ways is in the sources of histamine and also in the intermediaries.

Evidently, the histamine at the inflammatory site together with TH2 cures the inflammation.  Thus, histamine physiologically plays a role as type of switch for TH1 or TH2.          

IgE/mast cell/mediator path way12 (Fig. 3a) depicts the physiological path way which sets TH2 type of reaction after an allergic inflammation, there by affecting cure. Fig. 3b depicts pathological path way where in the presence of local cytokines IL4, IL6, INF etc., at the inflammatory site trigger the release of excess histamine over and above that required for maintaining histamine homeostasis.  This in turn triggers IgE B cells and in a cyclic manner contributes to release of more histamine making the inflammation chronic.  This in brief is the Rao’s vicious cycle proposed to be applicable for chronic inflammatory conditions.

            The IgG, IgM/Complement/neutrophil pathway as shown in Fig. 4, includes the pathological path 2b.  Typically IgG / IgM immune complex interacts with complement, which releases C3a and C5a and bring histamine and neutrophilis into the site. The presence of IL4, IL6, IL8 etc. at the inflammatory site trigger histamine and in turn the Rao’s Vicious Cycle.  The TH2 type of reaction, although, helps in healing process in physiological (2a) inflammation through the parenchymal cells, the excess of TH2 found in pathological inflammations can cause over healing, resulting in scaring and stiffening.

In the physiological path way 3a as shown in Fig. 5, theCD8 cells kill the intracellular organisms by TH1 type of reaction, and, the TH2 type of reaction set by histamine heals

through parenchymal cells. Pathological path 3b (T lymphocyte / lymphokine pathway) directly kills the intracellular organisms by TH1 reaction through the cytokines liberated by CD8 cells. However, the TH2 cytokines liberated from IgE B cells and the associated excess histamine through Rao’s Vicious cycle contribute to the chronic nature of inflammation.  Thus, in spite of the killing of intracellular organism (TH1 action) the inflammation continues (by TH2 action which opposes TH1).  The pain13, stress, and cancer cytokines are also the same as those that cause inflammation and, so can trigger Rao’s Vicious cycle.

 

Appa Hista:

            Appa Hista refers to the proposed method of curing inflammation using anti- histamine antibodies while exploiting the fundamental phenomena of Rao’s Vicious cycle.  It is by now clear that the histamine homeostasis in the body is disturbed during inflammation.  Antigen administered in the physiological condition of inflammation reacts with IgE B cells generating the IgE and in turn through TH2 type of reactions affecting the cure.  More serious is the pathological condition leading to chronic inflammation. Rao’s vicious cycle plays a major role in generating and maintaining histamine levels above those required for histamine homeostasis.  It is interesting to note that the generation of excess histamine is found in acute and chronic inflammation.  The cure therefore is to see that antibodies are generated to combat against histamine.  In Appa Hista method, histamine conjugated normal human immunoglobulin is intramuscularly injected. It works like a vaccine. This most likely reaches all the lymph nodes and stimulates B cells to produce IgG antihistamine antibodies (also referred to as Appa Hista).  The antibodies in turn reach the inflammatory site and neutralize the histamine i.e. it breaks the Rao’s vicious cycle, either directly or enhance the histamine binding ability of the plasma.  The histamine binding/ diluting ability is as high as 30 times in normal individuals as compared to that of suffering from allergic inflammation in normal individuals.14

            Appa Hista’s main advantage is that it neither interferes in primary histamine release nor causes any immuno suppression.  During the past two decades of clinical practice, the author had cured couple of hundreds of patients of both sexes with age groups ranging from 10 to 60 years. The relief from inflammatory diseases found in most cases range from good to excellent (patent application status). The intensity of the disease is found to be reduced on the administration of the medicine along with the gradual increase in the time periods at which the medicine has to be re-administered.  This may takes 3 weeks to 3 months depending up on the intensity of symptom.  An interesting feature is that the patients felt totally comfortable during in between drug administration periods along with a general feeling of well being, which was not the case with steroids or any other drugs.

 

Side effects:

            There are no side effects observed in the Appa Hista method of cure and applications.  It is however found that the method is not very effective in the case of smokers, and alcoholics. From an economic view point the treatment is inexpensive as compared to current day methods used.  Also, the drug, which is already bio-assayed and available in the market for last 30 years can be easily procured and administered.

            A link is observed among the inflammatory diseases and it is identified as Rao’s vicious cycle. Histamine is present in human body in levels corresponding to that required to maintain histamine homeostasis.  During inflammation, histamine is released at the- inflammatory sites as predicted by Rao’s vicious cycle. The later refers to the proliferation of TH2 type of reaction and its dominance over TH1 reaction.  In the Appa Hista method of cure, antihistamine antibodies combat the histamine at the inflammatory sites and also block TH2 type of reaction, thus indirectly helping the TH1 type of reaction. The dual effect of Appa hista antibodies can be visualized in:

1) killing the intracellular organisms through TH1 type of reaction, and,

2) neutralizing the histamine at inflammation site at the same time blocking the excess TH2 type of reaction.

Since Appa Hista directly attacks histamine where ever it is present, can cure all inflammatory diseases.

 

REFERENCES

 

1)      Espinoza, L. R. & Cuellar, M. L. Molecular Pathogenic Mechanisms of Spondyloarthropathies: (Medical Intelligence Unit). Publisher: (Springer,  Berlin, Germany), 125 pp (1995).

2)      Dr. Appa Rao Peddapalli. Use of Histamine Conjugated Normal Human Immunoglobulin for treatment of all types of pain and inflammation, Indian Patent Application: 3165/DEL/98, (1998).

3)      3) Dr. Appa Rao Peddapalli. Use of Histamine Conjugated Normal Human Immunoglobulin for treatment of all types of pain and inflammation, Indian Patent Application: 1301/DEL/2002, Dec 26th, (2002).

4)      3) Yoshii Haruo,  Fukata &  Yuriko. Immunomodulating and antiinflammatory agent. United States Patent 5,780,026  July 14, (1998).

5)      Valent, P.; et al. Variable expression of activation-linked surface antigens on human mast cells in health and disease.   Immunological Reviews, 179 74-81 (2001).

6)      Orth,  Reid N.; Wu, Min; Holowka, David, A.; Craighead, Harold, G. & Baird, Barbara A.  Mast Cell Activation on Patterned Lipid Bilayers of Subcellular Dimensions. Langmuir,   1599-1605 (2003).

7)      Falus, Andras; Laszlo, Valeria; Darvas, Zsuzsa & Bencsath, Martha. Histamine – an early messenger in the immune system and inflammation. Central-European Journal of Immunology, 52-54 (1996).

8)      Schneider, Elke; Rolli-Derkinderen, Malvyne; Arock, Michel & Dy, Michel.  Trends in histamine research: new functions during immune responses and hematopoiesis. Trends in Immunology,   255-263 (2002)

9)      Coge, Francis; et al. Genomic organization and characterization of splice variants of the human histamine H3 receptor. Biochemical Journal, 279-288 (2001).

10)  Mannaioni, P. F.; Fantozzi, R.; Giannella, E.; Masini, E. & Dep., Preclin. Pathophysiological significance of the distribution of histamine receptor sub-types:  a proposed dual role for histamine in inflammation and type I hypersensitivity reactions. Univ. Florence, Florence, Italy.    26-34 (1988).

11)  Lichtenstein, L. M. & Osler, A. G. Studies on the mechanisms of hypersensitivity phenomena. ix histamine release from human leukocytes by ragweed pollen antigen. Journal of Experimental Medicine. 507-30 (1964).

12)  De Rossi, Marco; Bernasconi, Pia; Baggi, Fulvio; De Waal Malefyt, Rene & Mantegazza, Renato.  Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation. International Immunology, 1329-1335 (2000).

13)  Schwarz, M.; Sunder-Plassmann R.; Cerwenka A.; Pickl, W. F. & Holter, W.Regulation of cytokine production by human T-lymphocytes in allergic immune response. Wiener Klinische Wochenschrift, General Review, 672-6 (1993).

14)  Dickenson, A. & Besson, J.M. The Pharmacology of Pain. Handbook, Exp. Pharmacol., Publisher: (Springer,  Berlin, Germany.) 479pp (1997). 

15)  Kokai Tokkyo Koho. Nippon Zoki Pharmaceutical Co. Ltd. Japan, Allergy treatment. Japanese Patent, Application: JP 78-162375  19781223,6 pp (1980).

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The less common forms of arthritis conditions include ankylosing sodalities, lupus, psoriatic arthritis, infectious arthritis, septic arthritis and many more. There are also a number of rheumatic syndromes associated with HIV infection. In some inflammatory forms of arthritis, the rheumatoid antibody, the marker for rheumatoid arthritis is not found in the blood serum. These forms are known collectively as exonerative arthritis, and include sodalities, Reiter’s disease and colitis arthritis, in which arthritis follows an infection. Sodality, which affects one person in a thousand, is a painful, progressive disease of the vertebrae of the spine.

 

As a result of the inflammation, scar tissue forms in the space between the vertebrae, making the joints stiff. This tissue may turn to bone so that when the inflammation dies down, it leaves bony deposits on the rims of the vertebrae. Bone grows from the ides of the affected vertebrae and may fuse together. If this arthritis is untreated, it can cause severe deformity of the spine with the sufferer bent forward, hardly able to look up. Sodalities affect many more men than women. Young men may develop the disease between ages of 17 and 27, typically in their early twenties. There is a strong genetic factor linked to a tissues type called HLA 827. However, not all those who carry the gene develop the full blown disease.

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Enclosing sodalities starts with persistent back pain and early morning stiffness that tends to become less with movement during the day. Symptoms may also include chronic fatigue and weight loss. There may be pain in the chest and ribs, making it difficult to breathe. Pain in the buttocks and the backs of the thighs, swollen ankles and tender heel bones may result. The condition should be treated promptly, to avoid locking of the spine. Blood tests and x-rays are used to make a definitive diagnosis. A relatively rare complication is iritic or unities, characterized by red, painful eyes. Go to hospital without delay if this happens to prevent permanent damage.

 

There is no cure for ankylosing spondylitis, although you can slow the condition’s advance by keeping mobile, and gain relief from pain through the application of heat. Hot baths, hot water bottles or an electric blanket, together with a firm bed, will prove helpful. Regular exercise, as advised by a physiotherapist, is important, so that even if fusion of the vertebrae takes place, the back fuses straight, rather than curved. When you are working at a desk, change your position frequently so that you are not holding your spine in one fixed position for long periods.